We also observed an increase in tau hyperphosphorylation and neuroinflammation, a disturbance of brain insulin signaling, and a decrease in synaptic plasticity and amyloid β peptides in the brain after STZ treatment. We found that STZ exacerbated impairment of short-term and spatial reference memory in 3xTg-AD mice. To investigate the role of metabolic insults in AD, we injected streptozotocin (STZ), a diabetogenic compound if used in the periphery, into the lateral ventricle of the 6-month-old 3xTg-AD mice and studied the cognitive function as well as AD-like brain abnormalities, such as tau phosphorylation and Aβ accumulation, 3–6 weeks later. Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD MiceĬhen, Yanxing Liang, Zhihou Tian, Zhu Blanchard, Julie Dai, Chun-ling Chalbot, Sonia Iqbal, Khalid Liu, Fei Gong, Cheng-XinĪlzheimer's disease (AD) involves several possible molecular mechanisms, including impaired brain insulin signaling and glucose metabolism.
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